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Volume Volume 17, 2023 · Issue 1 · Open Access · Double-blind Peer-review

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Hypothesis

Comparison of the effectiveness of topical Latanoprost and topical Minoxidil in treating Scalp Alopecia Areata in relation to CD8 cell expression: A study using clinical, dermoscopic, and immunohistochemical methods

Fatma M. Abd Allah1, Rabie B. Atta-Allah2, Salah El-din S. Semari3 & Osama M. El shahat2

1 Histology Department, Damietta Faculty of Medicine, Al-Azhar University, Egypt.

2 Dermatology, Venereology and Andrology Department, Damietta faculty of medicine, Al-Azhar University, Egypt.

3 Pathology Department, Damietta Faculty of Medicine, Al-Azhar University, Egypt.

* Corresponding author: Fatma M. Abd Allah ([email protected])

Published: 30 Jun 2023

https://doi.org/10.35192/jjoas-n.v17i1.1807
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Abstract

Background: Non-scarring hair loss on the scalp or any hair-bearing surface is the hallmark of the autoimmune disease Alopecia Areata (AA). Numerous approaches have been used to treat this condition, but the degree and duration of the illness determine how successful the treatments are.

Aim of the Study: We aimed to evaluate the efficacy of topical latanoprost versus topical minoxidil in treating patchy Alopecia Areata.

Patients and Methods: Thirty individuals with Alopecia Areata were randomly divided into two groups: Group A (15 patients) received topical latanoprost 1%, while Group B (15 patients) received topical minoxidil 5%. Dermoscopic imaging and a punch biopsy were taken and processed for histopathological and immunohistochemical studies, as well as to assess patient satisfaction to evaluate therapeutic response.

Results: Both treatment modalities demonstrated significant enhancement in all dermoscopic findings related to Alopecia Areata before and after therapy, with Group B showing much higher efficacy than Group A. In both treatment groups, immunohistochemically stained sections revealed a negative immunoreaction for CD8 T lymphocytes, indicating a reduction in inflammatory lymphocytic infiltration. Erythema and itching were the only insignificant side effects associated with both treatment regimens.

Conclusion: Both topical minoxidil and latanoprost are beneficial in promoting hair regrowth in patients with Alopecia Areata.

KeywordsAlopecia AreataMinoxidilLatanoprostDermoscopicMicroscopic

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